ea0016p655 | Signal transduction | ECE2008
Costantino Lucia
, Catalano Maria Graziella
, Frairia Roberto
, Boccuzzi Giuseppe
, Fortunati Nicoletta
Sex hormone-binding globulin (SHBG), the specific plasma carrier for sex steroids, regulates hormone bioavailable fraction and estrogen signalling system in breast cancer cells. A common single nucleotide polymorphism in the human SHBG gene results in an amino acid substitution (Asp327Asn), which introduces an additional N-glycosylation site that has been associated with reduced breast cancer risk in postmenopausal women. Since wild-type SHBG was demonstrated to interfe...